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December 2006/January 2007 Issue

• Space Radiation Poses Unknown Risks
• Nanotubes Pass First Hurdle
• Global Diabetes Unchecked
• Sex and the Brain

   
         

Space Radiation Poses Unknown Risks

By Ilene Raymond Rush
Editor-in-Chief
December 1, 2006



While NASA gears up for a planned 2020 expedition to the moon and a projected 2035 voyage to Mars, one possible deal breaker remains - cosmic radiation.

As spaceships and astronauts voyage beyond the Earth's protective magnetosphere, galactic cosmic radiation - which consists mostly of high-speed charged particles -- can deeply penetrate the body. Effects can range from acute episodes of radiation sickness to long-term problems with cataracts, cancer, sterility, and the central nervous system, as the rays rearrange genetic codes.

Without exact knowledge of the precise nature of cosmic radiation-induced health effects or the amount of exposure astronauts will undergo during long term missions, scientists remain unsure about other short and long-term damage - or how to stop it.

"Radiation isn't the only problem," says Marco Durante, PhD., professor of physics at the University of Federico II in Naples Italy and a researcher in space radiation and cancer. "But it is one of the most serious."

His colleague, Marcelo Vazquez, MD, PhD. who works for NASA and the Brookhaven National Lab agrees.

"It could be a show stopper," says Vazquez.

Unlike earlier missions, the 2020 journey to the lunar surface may last up to 200 days, while the planned Mars voyage may stretch to 3 years, opening up the exciting prospect of new sources of knowledge but also the danger of increased exposure to galactic cosmic rays.

Complicating matters, says Vasquez, is that space radiation, which involves heavy ions and unknown health effects, can only be studied by referring to data on earth radiation. Without first hand experience of the effect of particle showers on astronauts, researchers must extrapolate the effects of outer space radiation or rely on particle accelerators to replicate the effects.

"Our best models of the effects of ionizing radiation are based on what we have learned from survivors of atomic bombs," says Durante. "Luckily for us, the Japanese kept very good records. However, galactic cosmic rays are very different from atomic bomb radiation."

Risk estimates compare figures for an average population based on age-dependent and sex-dependent rates of death, combined with a model of radiation induced cancer mortality rates. But the two big unknowns - the quality of the radiation and the doses of radiation - remain uncertain.

The highest risk to astronauts during a moon mission will come from occasional solar particle events or showers, and adequate shielding may protect visitors. But on Mars, astronauts may be limited to about three hours away from a protected base before they go into a red planet alert from a radiation overexposure. According to an article by Durante and Francis Cucinotta, a NASA researcher in radiation, in the May 2006 issue of Lancet Oncology, on Mars "every cell nucleus in an astronaut's body would be hit by a proton or secondary electron every few days."

Acknowledging these dangers, both Durante and Vazquez note that several possibilities to shield astronauts may yet yield positive results - including drugs, dietary changes, and improved physical uniforms and structures. Yet much remains unknown and unsolved, waiting for further basic research in how the invasion of heavy radiation particles impacts the body's cells.

Given the inherent dangers of space travel, why bother? Both Durante and Vazquez respond to the oft-asked question.

"For knowledge for sure," says Durante. "But exploration is in man's nature and without it, we would not be fully human. It's part of who we are."

For more see:
Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beings
Cucinotta FA, Durante M
Lancet Oncology - Vol. 7, Issue 5, May 2006, Pages 431-435

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December 2006/January 2007


Nanotubes Pass First Hurdle

By Ilene Raymond Rush
Editor-in-Chief
December 1, 2006



Carbon nanotubes injected directly into animals will pass through the bloodstream, which may make them useful in delivering medications and in diagnosing disease, according to researchers at Rice University.

"We sampled tissues from a dozen organs after 24 hours, and found significant amounts of nanotubes only in the liver," said lead author Bruce Weisman, professor of chemistry, in a prepared release. "The liver naturally removes drugs or compounds from the blood, so this is what we expected to find."

Nanotubes are hollow cylinders of pure carbon that measure only a few nanometers in length and 1 nanometer in diameter - about the same width as a strand of DNA. Nanotubes have unique chemical and optical properties (they give off light) and they have attracted intense interest from biomedical researchers.

For more see:
http://news.com.com

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December 2006/January 2007


Global Diabetes Unchecked

By Ilene Raymond Rush
Editor-in-Chief
December 1, 2006



Global diabetes cases are anticipated to rise from 246 million to 380 million in twenty years, with 80 percent of new cases coming in newly affluent developing countries, according to a new "Diabetes Atlas" presented at the World Diabetes Congress in Cape Town.

"This is an epidemic that seems to have crept up on people," says Martin Silink, incoming president of the International Diabetes Federation, speaking to Reuters. "The enormity of the epidemic has suddenly become apparent to everyone."

Diabetes, which affects the body's ability to utilize or produce insulin, a key element in processing glucose, is responsible for the deaths of 3.8 million people each year, mostly due to heart attacks and strokes. Seven million people per year develop diabetes, often in developing countries where economic growth brings 'lifestyle diseases' once mainly found in richer countries.

Experts still recommend that people watch their diets and increase their exercise to fight the epidemic.

Highlights of the Atlas include:

• Type 2, or adult onset diabetes, is spreading most quickly in the Eastern Mediterranean and Middle East.

• India and China have the world's greatest number of diabetics, at about 40 million apiece.

• By 2025, South America is expected to double its rate of diabetes. Africa will see an 80 percent increase and the Indian sub-continent a 56 percent higher rate.

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December 2006/January 2007


Sex and the Brain

By Ilene Raymond Rush
Editor-in-Chief
December 1, 2006



Gender has emerged as an important influence on brain function, chemistry and anatomy, according to a rapidly growing body of scientific literature.

Brain imaging techniques, which have allowed researchers to peer deeply into the brain, have revealed that sex influences neuronal functions for which the gender of subjects was once considered unimportant.

A recent study by University of L'Aquila (Italy) researchers examined the effects of emotional material on declarative memory, the part of memory concerned with facts and experiences, and found gender influenced brain response.

"Our findings documented new and surprising gender influences on the brain," says Antonella Gasbarri, lead author and full professor in the Department of Biomedical Sciences and Technologies. "We found that gender is a crucial variable in understanding cerebral hemisphere function, in particular in relation to emotional conditions."

Differences between brain activity in men and women were so marked that Gasbarri recommends that future studies account for menstrual cycles, which may affect brain activity responses in female subjects.

The results, which confirm and extend earlier work in the area, could lead to sex-specific treatment for many conditions and have important implications on the treatment of addiction, depression, schizophrenia and post-traumatic stress disorder, according to Gasbarri.

In the study, researchers presented men and women with two stories, one neutral and one emotional. Both stories used the same set of slides, which were explained through a narrative. The same stories have been earlier employed in experiments with brain damaged and healthy adult subjects, involving the enhancing effects of emotions on memory retention.

To measure the effect of the stories on declarative memory, researchers measured ERPs (event-related potentials), the electrical activity produced by the brain in response to a sensory stimulus. Investigators sought to evaluate if men and women showed a different sex-related hemispheric lateralization of electrical potentials elicited by the emotional content of the story.

"Our findings underline the view that that the influences of both sex and cerebral hemisphere have to be considered in future studies of neural correlates of emotion and of emotion's relation to memory," says Gasbarri.

For more see:

Gasbarri, A., Arnone, B., Pompili, A., Marchetti, A., Pacitti, F., Saad Calil, S., Pacitti, C., Tavares M.C., Tomaz, C.
Sex-related lateralized effect of emotional content on declarative memory: an event related potential study.
Behav. Brain Res, 2006; 168: 177-184.

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